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Science: Cannabinoids may be useful in some forms of diarrhea

Cannabinoids decrease secretion in the small intestine. Thus, "they may have therapeutic potential for diarrhea unresponsive to available therapies," researchers of the Oklahoma Foundation for Digestive Research in Oklahoma City/USA say in an article for the European Journal of Pharmacology, issue of 8 December.

In vitro electrical stimulation induced secretion in the small intestine of rats, that was attenuated by a Cannabinoid (WIN 55212-2). This inhibition of secretion was reversed by SR141716A, a cannabinoid-1- receptor-antagonist. Secretion stimulated by acetylcholine was unaffected by the Cannabinoid.

These findings show that Cannabinoids inhibit neurally mediated secretion via Cannabinoid CB1-receptors and may be useful in some forms of diarrhea.

(Source: Tyler K, et al: Inhibition of small intestinal secretion by Cannabinoids is CB(1) receptor-mediated in rats. Eur J Pharmacol 2000;409:207-211)

*Industrial-Hemp has no psychoactive properties following definition of the European Economic Community (EEC); THC content is less than 0.3%. In general, low THC-seed varieties without psychoactive properties are those that have a THC content of less than 1%. (See also No-THC Hemp-seed.) THC Delta-9 TetraHydroCannabinol.